L8226-100UG - MAUROTOXIN
(Syn. : MTx, Potassium channel toxin alpha-KTx 6.2)
(Syn. : MTx, Potassium channel toxin alpha-KTx 6.2)
MAUROTOXIN | Product ID | L8226-100UG |
| Name | MAUROTOXIN |
| Molecular formula | C145H231N45O47S8 |
| Description |
A 34 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Large-clawed scorpion Scorpio maurus palmatus. |
| Biological activity | Maurotoxin is a member of the α-KTx6.2 scorpion toxin family. It blocks voltage-gated potassium channels (KV1.1/KCNA1, KV1.2/KCNA2, and KV1.3/KCNA3) and inhibits apamin-sensitive small conductance calcium-activated channels (SK channels), particularly KCa3.1 (IKca1, SK4). The blockage of Kv1.2 occurs with high affinity. Maurotoxin has not the same disulfide pairing as other members of alpha-KTx 6. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 151.00 | ||
| 5 Unité(s) | 604.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8226-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8226-100UG | Molecular weight | 3612.55 Da |
| Product name | MAUROTOXIN | Physical form | White lyophilized solid |
| CAS No. | 188240-41-7 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P80719 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8226-100UG |
| Product name | MAUROTOXIN |
- 1. Blanc, E., et al. (1997) Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels, Proteins. ;
2. Carlier, E.,et al. (2000) Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels, J Pept. ;
3. Fajloun Z, et al., (2011) Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K(+) channel. J Pept Sci. ;
4. Rochat, H., et al. (1998) Maurotoxin, a four disulfide bridges scorpion toxin acting on K+ channels, Toxicon.
Links
| Product code | L8226-100UG |
| Product name | MAUROTOXIN |
| External Links |
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Toxicology Citations From PubMed
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