L8127-100UG - DISINTEGRIN OBTUSTATIN
(Syn. : Obtustatin)
(Syn. : Obtustatin)
DISINTEGRIN OBTUSTATIN | Product ID | L8127-100UG |
| Name | DISINTEGRIN OBTUSTATIN |
| Molecular formula | C184H284N52O57S8 |
| Description |
A 41 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Levant blunt-nosed viper Vipera lebetina obtusa. |
| Biological activity | A potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC50 of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin. It does not show inhibitory activity toward alpha-2/beta-1 (ITGA2/ITGB1), alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), alpha-4/beta-1 (ITGA4/ITGB1), alpha-5/beta-1 (ITGA5/ITGB1), alpha-6/beta-1 (ITGA6/ITGB1), and alpha-9/beta-1 (ITGA9/ITGB1), alpha-4/beta-7 (ITGA4/ITGB7) integrins. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 190.00 | ||
| 5 Unité(s) | 760.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8127-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8127-100UG | Molecular weight | 4393.13 Da |
| Product name | DISINTEGRIN OBTUSTATIN | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | aqueous buffer |
| UNIPROT | P83469 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90488962 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8127-100UG |
| Product name | DISINTEGRIN OBTUSTATIN |
- 1. Brown MC, et al. (2008) Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth. Int J Cancer. ;
2. Calvete JJ, et al. (2007) KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin. Curr Pharm Des. ;
3. Daidone I, et al. (2013) Structural and dynamical properties of KTS-disintegrins: A comparison between Obtustatin and Lebestatin. Biopolymers. ;
4. Marcinkiewicz C., et al. (2003) Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo. Cancer Res. ;
5. Moreno-Murciano M.P., et al. (2003) Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci. ;
6. Moreno-Murciano M.P., et al. (2003) NMR solution structure of the non-RGD disintegrin obtustatin. J. Mol. Biol.
Links
| Product code | L8127-100UG |
| Product name | DISINTEGRIN OBTUSTATIN |
| External Links |
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