L8121-100 UG - MAMBALGIN-1
(Syn. : Mamb-1, Pi-Dp1)
(Syn. : Mamb-1, Pi-Dp1)
MAMBALGIN-1 | Product ID | L8121-100 UG |
| Name | MAMBALGIN-1 |
| Molecular formula | C272H429N85O84S10 |
| Description |
A 57 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Black mamba Dendroaspis polylepis polylepis. |
| Biological activity | A potent and selective blocker of acid-sensing ion channels (ASIC). ASIC channels have been demonstrated to be implied in pain pathways and appear to be promising therapeutic targets. Mambalgin-1 It reversibly inhibits rat ASIC1a (IC50=3.4-55 nM), rat ASIC1a-ASIC2b (61 nM), rat ASIC1a-ASIC1b (72 nM), human ASIC1a (127-580 nM), rat ASIC1b (22.2-203 nM), rat ASIC1a-ASIC2a (152-252 nM). Mambalgin-1 has no effect on ASIC2a, ASIC3, ASIC1a+ASIC3 and ASIC1b+ASIC3 channels, as well as on TRPV1, P2X2, 5-HT3A, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin-1 differs from mambalgin-2 by one amino acid. Both have demonstrated a similar activity. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 250.00 | ||
| 5 Unité(s) | 1 000.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8121-100 UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8121-100 UG | Molecular weight | 6554.59 Da |
| Product name | MAMBALGIN-1 | Physical form | White lyophilized solid |
| CAS No. | 1609937-15-6 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P0DKR6 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 121513904 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
||
| Savety Recommandations | |||
Bibliographic References
| Product code | L8121-100 UG |
| Product name | MAMBALGIN-1 |
- 1. Diochot S., et al. (2012) Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature. ;
2. Salinas M., et al. (2014) Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. JBC. ;
3. Wen M., et al. (2015) Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun.
Links
| Product code | L8121-100 UG |
| Product name | MAMBALGIN-1 |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
 UNIPROT |
