(Syn. : CRT)
CROTAMINE CRO 2 | Product ID | L8118 |
| Name | CROTAMINE CRO 2 |
| Molecular formula | C214H326N64O54S7 |
| Description |
A 42 amino-acids peptide with 3 disulfide bridges , purified from the venom of the South American rattlesnake Crotalus durissus terrificus |
| Biological activity | As a potassium channel inhibitor, Crotamine selectively inhibits Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 channels with an IC50 of 369, 386 and 287 nM respectively. Crotamine is also a fast cell-penetrating peptide (CPP) with high specificity for actively proliferating cells. To enter the cell, it interacts with the chains of heparan sulfate membrane proteoglycan (HSPG), and is then endocytosed in vesicles which are transported into the cell with the help of clathrin. Inside the cell, crotamine accumulates in lysosomal vesicles causing their disruption at high concentrations. Crotamine shows antibacterial activity against E. coli and B. subtilis, and antifungal activity against Candida spp., Trichosporon spp. and C. neoformans. It kills bacteria through membrane permeabilization. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 170.00 | ||
| 5 Unité(s) | 680.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8118 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8118 | Molecular weight | 4883.82 Da |
| Product name | CROTAMINE CRO 2 | Physical form | White lyophilized solid |
| CAS No. | 58740-15-1 | Melting point | |
| RTECS | GP9046000 | Solubility | water and saline buffer |
| UNIPROT | Q9PWF3 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 85470858 | ||
| Purity | > 92 % | ||
| Toxicity(LD50) | |||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8118 |
| Product name | CROTAMINE CRO 2 |
- 1. De Lucca FL., et al. (1974) Characterization of ribonucleic acids from the venom glands of Crotalus durissus terrifucus (Ophidia, Reptilia) after manual extraction of the venom. Studies on template activity and base composition. Biochem J. ;
2. Hayashi MA., et al. (2012) Crotamine: a novel cell-penetrating polypeptide nanocarrier with potential anti-cancer and biotechnological applications. Methods Mol Biol. ;
3. Kerkis A., et al. (2004) Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus. FASEB J. ;
4. Kerkis I., et al. (2010) Biological versatility of crotamine a cationic peptide from the venom of a South American rattlesnake. Expert Opin Investig Drugs. ;
5. Kerkis I., et al. (2014) State of the art in the studies on crotamine, a cell penetrating peptide from South American rattlesnake. Biomed Res Int. ;
6. Mancin AC., et al. (1998) Â The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. ;
7. Nascimento FD (2012) The natural cell-penetrating peptide crotamine targets tumor tissue in vivo and triggers a lethal calcium-dependent pathway in cultured cells. Mol Pharm.
Links
| Product code | L8118 |
| Product name | CROTAMINE CRO 2 |
| External Links |
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