It is a blocker of Ca²⁺-activated K⁺ channels of high conductance and some voltage-dependent K⁺ channels.
In human and murin beta-lymphocytes, where both K⁺ channels subtypes are present, Kaliotoxin is a selective voltage-dependent K⁺ channels blocker.

In neurons: KTX blocks the invertebrate and mammalian sympathetic high conductance K⁺ channels with a Kd of 2 to 4 nM. These effects were observed on the whole-cell current as well as on the unitary channel activity.
KTX inhibits the shaker K⁺ current resulting from mRNA expression in Xenopus oocyte with a Kd of 2 to 5 nM.
The radiolabelled derivative ¹²⁵I KTX binds to the rat brain synaptosomal membrane (Kd = 10 pM) and it is displaced by Dendrotoxin with a Kd of 8 pM.

In muscle: KTX is poorly active on skeletal high conductance K⁺ channels incorporated in lipid bilayers.

In lymphocytes: in human and murin b-lymphocytes, where both Ca²⁺-activated K⁺ channels and voltage-dependent K⁺ channels are present, KTX selectively inhibits the activity of the voltage-dependent K⁺ channels with a Kd of 1 to 5 nM.

Stable in freeze-dried state.
In solution, keep at -20 °C.

For research use only — not intended for food, diagnostic or therapeutic use