L8211-100UG - IBERIOTOXIN
(Syn. : IbTx, Potassium channel toxin alpha-KTx 1.3)
(Syn. : IbTx, Potassium channel toxin alpha-KTx 1.3)
IBERIOTOXIN | Product ID | L8211-100UG |
| Name | IBERIOTOXIN |
| Molecular formula | C179H274N50O55S7 |
| Description |
It is a highly selective blocker of the high conductance Ca2+-activated K+ channel. Iberiotoxin appears to modulate ChTX binding by an allosteric mechanism. 37-amino acid peptide with 3 disulfide bridges. Synthetic, originally from Buthus tamulus scorpion venom. |
| Biological activity | As a specific blocker of Ca2+-activated K+ channels, Iberiotoxin does not affect other types of voltage-dependent K+ channels which are sensitive to inhibition by Charybdotoxin. Iberiotoxin blocks Ca2+-activated K+ channels by binding to their external mouth, and this binding is tighter and with an equilibrium dissociation constant 10-fold lower than that of Charybdotoxin. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8211-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8211-100UG | Molecular weight | 4,230.85 Da |
| Product name | IBERIOTOXIN | Physical form | |
| CAS No. | 129203-60-7 | Melting point | |
| RTECS | Solubility | In water and saline | |
| UNIPROT | P24663 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | 99 % (HPLC) | ||
| Toxicity(LD50) | |||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
|||
| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
||
Bibliographic References
| Product code | L8211-100UG |
| Product name | IBERIOTOXIN |
- Galvez et al., "Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus." J. Biol. Chem. (1990) 265(19):11083-11090
- Candia et al., "Mode of action of Iberiotoxin, a potent blocker of the large conductance Ca2+-activated K+ channel." Biophys. J. (1992). 63:583-590
Links
| Product code | L8211-100UG |
| Product name | IBERIOTOXIN |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
 UNIPROT |
