(Syn. : BTX)
BATRACHOTOXIN | Product ID | L8301 |
| Name | BATRACHOTOXIN |
| Molecular formula | C31H42N2O6 |
| Description |
The strongest sodium channel activator so far Alkaloid with a steroid skeleton, an oxazapine ring and a dimethylpyrrole carboxylate moiety , purified from skin extract of the poison dart frog Phyllobates terribilis |
| Biological activity | BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation. BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar. BTX binding induces many allosteric effects on other channel regions, and increases the binding of scorpion alpha-toxins to receptor site-3, of Brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7. Research tool applicable to the study of the function of sodium channel and the effects of other toxins and of a variety of drugs, including anesthetics, analgesics, antiarrhythmics, anticonvulsants and antidepressants. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 x 10 µg | 75.00 | ||
| 1 x 20 µg | 125.00 | ||
| 5 x 10 µg | 300.00 | ||
| 1 x 100 µg | 340.00 | ||
| 5 x 20 µg | 500.00 | ||
| 5 x 100 µg | 1 360.00 | ||
| 1 x 500 µg | 1 360.00 | ||
| 1 x 1 mg | 2 600.00 | ||
| 5 x 500 µg | 5 440.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8301 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8301 | Molecular weight | 538.67 g/mol |
| Product name | BATRACHOTOXIN | Physical form | Film |
| CAS No. | 23509-16-2 | Melting point | |
| RTECS | CR3990000 | Solubility | In ethanol, methanol and DMSO |
| UNIPROT | Optical Activity | [alpha]D29 300 - 260° (c = 0.23 in methanol) | |
| PubChem SID | |||
| PubChem CID | 31958 | ||
| Purity | > 90 % (HPLC, TLC, Toxicity) | ||
| Toxicity(LD50) | IPR-MUS LD50: 2 μg/kg | ||
| Chemical Name | 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate) | ||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C dissolve in ethanol or methanol |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8301 |
| Product name | BATRACHOTOXIN |
- T. Tokuyama et al, J. Am Chem. Soc 91:3931 (1969)
- E. X. Albuquerque et al, Science 172:995 (1971)
- W. A. Catterall et al, J. Biol. Chem. 256:8922(1981)
- T. Tokuyama and J.W. Daly, Tetrahedron 39:41-47 (1983)
- G.B. Brown, Internat. Rev. Neurobiol. 29: 77-116 (1988)
- M. Kurosu et al., J. Am Chem.. Soc. 120: 6629 (1998)
- S. J. Wang and G. K. Wang, Cellular Signaling 15: 151 (2003)
- Batrachotoxin. RN 23509-16-2. STN Registry file (27 February 2006)
Links
| Product code | L8301 |
| Product name | BATRACHOTOXIN |
| External Links |
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