(Syn. : Mca)
MAUROCALCINE | Product ID | L8225-100UG |
| Name | MAUROCALCINE |
| Molecular formula | |
| Description |
It is an activator of Ca2+ release channel and so a Ryanodine receptors agonist. 33-mer basic peptide cross-linked by three disulphide bridges , synthetic, originally from Scorpio maurus palmatus scorpion venom |
| Biological activity | It is an agonist of Ryanodine receptor type 1, 2 and 3. It potently and reversibly modifies channel gating behaviour of the type 1 Ryanodine receptor (RyR1) by inducing increased opening probabilities and a prominent subconductance behaviour. Class of biological activity: Ca2+ channel activator. Field of use: It has a therapeutic potential, notably as candidate immuno-suppressive drugs and for the treatment of diseases induced by dysfunction of calcium channels, in men. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 141.00 | ||
| 5 Unité(s) | 564.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8225-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8225-100UG | Molecular weight | 3857.2 Da |
| Product name | MAUROCALCINE | Physical form | White powder |
| CAS No. | Melting point | ||
| RTECS | Solubility | In aqueous solution | |
| UNIPROT | P60254 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | > 99 % (HPLC) | ||
| Toxicity(LD50) | ICV-MUS LD50: 1 mg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at -20 °C.
Reconstitution recommendations: in aqueous solution.
in aqueous solution. |
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| Savety Recommandations | Use gloves, wear mask, manipulate under hood. |
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Bibliographic References
| Product code | L8225-100UG |
| Product name | MAUROCALCINE |
- Fajloun Z, Kharrat R, Chen L et al. Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca2+ release channel / ryanodine receptors. FEBS Letters 469: 179-185 (2000).
- Chen L, Estève E, Sabatier JM et al. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1 (RyR1) revealing a proportional gating mechanism. Journal of Biological Chemistry 278: 16095-16106 (2003).
- Estève E, Smida-Rezgui S, Sarkozi S et al. Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. Journal of Biological Chemistry 278: 37822-37831 (2003).
- Estève E, Mabrouk K, Dupuis A et al. M.Transduction of the scorpion toxin maurocalcine into cells – Evidence that the toxin crosses the plasma membrane. Journal of Biological Chemistry 280: 12833-12839 (2003).
- Szappanos H, Smida-Rezgui S, Cseri J et al. Differential effects of Maurocalcine on Ca2+ release events and depolarisation induced Ca2+ release in rat skeletal muscle. Journal of Physiology 565: 843-853 (2005).
- Boisseau S, Mabrouk K, Garmy N et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochimica Biophysica Acta Biomembranes 1758 : 308-319 (2005).
Links
| Product code | L8225-100UG |
| Product name | MAUROCALCINE |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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