IMPERIALINE Iodomethylate
Product ID L6228 
Name IMPERIALINE Iodomethylate 
Molecular formula C28H46NO3I
Description

It is a highly active peripheral M2-cholinoblocker


Alkaloid , derived from Imperialine extracted from Petilium eduardi and Petilium raddeanae (Liliaceae family)
Biological activity

Practical: It may be used as bioreactive in radioligand methods of investigations for binding of peripheral M2-cholinoreceptors (without acting on CNS). It can be used for investigation of modulatory role of M2-cholinoreceptors on functional activity of different organs.
Theoretical: In view of its selectivity to M2-subtype muscarinic receptors and of its poor penetration in brain, Imperialine Iodomethylate is optimal for elimination of undesirable, sometimes dangerous, vagal effects on heart.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
5 mg 528.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6228 : unit price : free of charge
 Chemical and Physical Properties
Product code L6228  Molecular weight 571 g/mol
Product name IMPERIALINE Iodomethylate  Physical form Fine crystalline white powder
CAS No. Melting point 254-255 °C
RTECS Solubility Soluble in chloroform, ethanol, methanol
Poorly in acetone and water
UNIPROT Optical Activity Not determined
PubChem SID    
PubChem CID 52993655    
Purity 95% (TLC)    
Toxicity(LD50) IVN-MUS LD50: 16,4 (13,2 - 19,8) mg/kg    
Chemical Name 3,20-dioxy, 6-one, N-iodemethylate-cevanine    
Storage & Reconstitution
Recommandations

Store in dark, cool and dry place
Reconstitution: Prepare a basic 0.1 % solution in HCl. Can be prepared with heating


Basic 0,1% solution in HCl can be prepared with heating
 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6228 
Product name IMPERIALINE Iodomethylate 

- R.Eglen et al, Naunyn-Schmiedebergs Arch. Pharmacol.(1992), 348: 144 – 152
- Yu.R.Mirzayev. Third International Symposium on the Chemistry of Natural Compounds (SCNC), 19-22 Oct.,Uzbekistan, 1998, p. 96
- A.Roffel et al. Fundam and Clin.Pharmacol., v.3, No 4, p.404
 Links
Product code L6228 
Product name IMPERIALINE Iodomethylate 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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