DIHYDROATISINE HCl | Product ID | L6249 |
| Name | DIHYDROATISINE HCl |
| Molecular formula | C22H35NO2 . HCl |
| Description |
It is an antiarrhythmic of Ia and IV classes as a blocker of TTX sensitive Na+channels and a Ca++ antagonist.
Diterpene alkaloid purified from Aconitum seravschanicum Steinb, (Ranunculaceae fam.) |
| Biological activity | It is a potent antiarrythmic in experimental calcii chloridum-induced atrial flutter, aconitine-induced arrhythmia, strophantinum-induced tachiarrythmia and at left descendent coronary artery occlusion in dogs. By its antiarrhythmic activity and therapeutic width Dihydroatizine hydrochloride surpasses activity of known Ia class antiarrhythmics such as quinidine, procainamide, ajmaline and lydocaine, as well as activity of IV class antiarrhythmic such as calcium blocker verapamile. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 20 mg | 104.00 | ||
| 100 mg | 416.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6249 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6249 | Molecular weight | 381.24-383.24 g/mol |
| Product name | DIHYDROATISINE HCl | Physical form | white crystalline powder |
| CAS No. | 4758-99-0 | Melting point | 240 - 242 °C |
| RTECS | Solubility | Poor in ethanol Better in methanol and water |
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| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 73388 | ||
| Purity | >97% | ||
| Toxicity(LD50) | IVN-MUS LD50: 20,4 mg/kg IPR-MUS LD50: 88,0 mg/kg ORL-MUS LD50: 348,0 mg/kg |
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| Chemical Name | 4bMethyl-N-(b-oxy-)ethylatisane hydrochloridum | ||
| Storage & Reconstitution Recommandations |
Store in dark, cool place soluble in weak acidic solvent |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L6249 |
| Product name | DIHYDROATISINE HCl |
- Vaisov Z., Salimov B., Tashkhodzhaev B., Yunusov M.; Khim. Prir. Soedin. (1986), p.653-658
- Salimov B., Kuzibaeva J., Dzhakhangirov F.; Khim. Prir. Soedin.(1996), p.384
- Dzhakhangirov F., et al. ; Khim. Prir. Soedin.(1996), special issue. P.180
Links
| Product code | L6249 |
| Product name | DIHYDROATISINE HCl |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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