LEUCOMISINE
Product ID L6067 
Name LEUCOMISINE 
Molecular formula C15H18O3
Description

It is an antiatherosclerotic, a angioprotective, a hypolipidemic and an anti-inflammatory.


Sesquiterpene lactone , from plants of the Compositae family.
Biological activity

1 mg/kg during 90 days decrease the size and thickness of atherosclerotic discs, the amount of foam cells and the cholesterol content in aorta of rabbits fed with high cholesterol level diet. It also reduces the permeability increase of aorta and microvessels for high molecular weight albumin-Blue Evans complex caused by Cholesterol, Bradykinin, Ovalbumin or Histamine.
In blood serum and in liver, Leucomisine also presents an hypolipidemic activity on all major lipid classes, especially esters of cholesterols.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
100 mg 120.00

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500 mg 480.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6067 : unit price : free of charge
 Chemical and Physical Properties
Product code L6067  Molecular weight 246.30 g/mol
Product name LEUCOMISINE  Physical form Powder
CAS No. 17946-87-1 Melting point 199-200 °C
RTECS ME6355000 Solubility In chloroform, acetone, ethylacetate, benzole
Not in water
UNIPROT Optical Activity [alpha]D20 + 56° (c = 1.5 in chloroform)
PubChem SID    
PubChem CID 167683    
Purity 98 %    
Toxicity(LD50) ORL-MUS LD50: 5 000 mg/kg    
Chemical Name Guaia-1(10),3-dien-12-oic acid, 6-alpha-hydroxy-2-oxo-, gamma-lactone, (11S)-    
Storage & Reconstitution
Recommandations

Store at +4°C, in dark place.


 
Savety Recommandations

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use

 
 Bibliographic References
Product code L6067 
Product name LEUCOMISINE 

- Rybalko. J. obsh. Khimiya (1963)(Russian) 33(8):2734
- Kurmukov et al., Pharmacol. Toxicol. (1991) (Russian). 54(3):35-37
 Links
Product code L6067 
Product name LEUCOMISINE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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